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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Mark4 Antibody (C-term)   

Mouse Mark4 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Mark4 Antibody (C-term) AP16077B
    Mouse Mark4 Antibody (C-term) (Cat. #AP16077b) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the Mark4 antibody detected the Mark4 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8CIP4
Other Accession NP_758483.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 82644 Da
Antigen Region 606-633 aa
Additional Information
Gene ID 232944
Other Names MAP/microtubule affinity-regulating kinase 4, Mark4, Kiaa1860
Target/Specificity This Mouse Mark4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 606-633 amino acids from the C-terminal region of mouse Mark4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Mark4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mark4
Synonyms Kiaa1860
Function Serine/threonine-protein kinase (By similarity). Phosphorylates the microtubule-associated protein MAPT (By similarity). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (By similarity). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (By similarity). Required for the initiation of axoneme extension during cilium assembly (By similarity). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (By similarity). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (By similarity). Reduces neuronal cell survival (By similarity). Plays a role in energy homeostasis by regulating satiety and metabolic rate (PubMed:22992738). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (PubMed:24989893). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (By similarity).
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q96L34} Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q96L34}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q96L34}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q96L34}. Cytoplasm {ECO:0000250|UniProtKB:Q96L34}. Note=Localized at the tips of neurite-like processes in differentiated neuroblast cells Detected in the cytoplasm and neuropil of the hippocampus {ECO:0000250|UniProtKB:Q96L34}
Tissue Location Isoform 1 and isoform 2 show similar expression patterns in the central nervous system and are present in the same subsets of neurons including pyramidal and non- pyramidal neurons in the cerebral cortex and hippocampus, cerebellar Purkinje cells, and interneurons and motor neurons in the spinal cord but not in glial cells (at protein level) (PubMed:16973293). Isoform 2 is the major isoform in brain and cerebellum (PubMed:16973293, PubMed:15009667). Also expressed in spleen, liver, small intestine, colon, kidney, tongue, testis and lung (PubMed:16973293, PubMed:15009667). Isoform 1 and isoform 2 are expressed at similar levels in heart (PubMed:16973293)
Research Areas
Citations (0)

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References

Schneider, A., et al. J. Neurochem. 88(5):1114-1126(2004)
Zambrowicz, B.P., et al. Proc. Natl. Acad. Sci. U.S.A. 100(24):14109-14114(2003)
Okazaki, N., et al. DNA Res. 10(1):35-48(2003)
Stryke, D., et al. Nucleic Acids Res. 31(1):278-281(2003)
Lee, Y.J., et al. FEBS Lett. 472 (2-3), 230-234 (2000) :

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Cat# AP16077B
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