|Application ||WB, E|
|Other Accession||NP_001098547.3, NP_001098548.2|
|Calculated MW||118276 Da|
|Antigen Region||1-30 aa|
|Other Names||MDS1 and EVI1 complex locus protein EVI1, Ecotropic virus integration site 1 protein homolog, EVI-1, MECOM, EVI1|
|Target/Specificity||This EVI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human EVI1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EVI1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.|
|Cellular Location||Nucleus. Nucleus speckle.|
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Provided below are standard protocols that you may find useful for product applications.
EVI1 functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.
Gomez-Benito, M., et al. Br. J. Cancer 103(8):1292-1296(2010) Meyer, T.E., et al. PLoS Genet. 6 (8) (2010) : Goyama, S., et al. Int. J. Hematol. 91(5):753-757(2010) Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) : Haas, K., et al. Genes Chromosomes Cancer 47(4):288-298(2008)
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