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EVI1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q03112 |
| Other Accession | NP_001098547.3, NP_001098548.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 138136 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 2122 |
|---|---|
| Other Names | MDS1 and EVI1 complex locus protein EVI1, Ecotropic virus integration site 1 protein homolog, EVI-1, MECOM, EVI1 |
| Target/Specificity | This EVI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human EVI1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EVI1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MECOM (HGNC:3498) |
|---|---|
| Function | [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. |
| Cellular Location | Nucleus. Nucleus speckle. Cytoplasm |
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Provided below are standard protocols that you may find useful for product applications.
Background
EVI1 functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.
References
Gomez-Benito, M., et al. Br. J. Cancer 103(8):1292-1296(2010) Meyer, T.E., et al. PLoS Genet. 6 (8) (2010) : Goyama, S., et al. Int. J. Hematol. 91(5):753-757(2010) Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) : Haas, K., et al. Genes Chromosomes Cancer 47(4):288-298(2008)
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