|Application ||WB, E|
|Other Accession||P54759, Q15375, O42422|
|Calculated MW||111860 Da|
|Antigen Region||113-140 aa|
|Other Names||Ephrin type-A receptor 7, Developmental kinase 1, mDK-1, EPH homology kinase 3, EHK-3, Embryonic brain kinase, EBK, Epha7, Ebk, Ehk3, Mdk1|
|Target/Specificity||This Mouse Epha7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-140 amino acids from the N-terminal region of mouse Epha7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Epha7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Ebk, Ehk3, Mdk1|
|Function||Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. Isoform 4 which lacks the kinase domain may regulate isoform 1 adhesive properties.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Widely expressed in embryo. In adult, expression restricted to hippocampus, testis and spleen|
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Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A2, -A3, -A4 and -A5.
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