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SEC14L2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SEC14L2 Antibody (N-term) AP16118a
    SEC14L2 Antibody (N-term) (Cat. #AP16118a) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the SEC14L2 antibody detected the SEC14L2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O76054
Other Accession Q99MS0, Q99J08, P58875, NP_036561.1, NP_203740.1
Reactivity Mouse
Predicted Bovine, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46145 Da
Antigen Region 41-69 aa
Additional Information
Gene ID 23541
Other Names SEC14-like protein 2, Alpha-tocopherol-associated protein, TAP, hTAP, Squalene transfer protein, Supernatant protein factor, SPF, SEC14L2, C22orf6, KIAA1186, KIAA1658
Target/Specificity This SEC14L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-69 amino acids from the N-terminal region of human SEC14L2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSEC14L2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SEC14L2
Synonyms C22orf6, KIAA1186, KIAA1658
Function Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
Cellular Location Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha- tocopherol
Tissue Location Widely expressed. Strong expression in liver, brain and prostate.
Research Areas
Citations (0)

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This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.


Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Wang, X., et al. Cancer Invest. 27(10):971-977(2009)
Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
Johnykutty, S., et al. Mod. Pathol. 22(6):770-775(2009)
Wright, M.E., et al. Cancer Res. 69(4):1429-1438(2009)

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Cat# AP16118a
(40 western blots)
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