|Application ||WB, E|
|Other Accession||Q99MS0, Q99J08, P58875, NP_036561.1, NP_203740.1|
|Calculated MW||46145 Da|
|Antigen Region||41-69 aa|
|Other Names||SEC14-like protein 2, Alpha-tocopherol-associated protein, TAP, hTAP, Squalene transfer protein, Supernatant protein factor, SPF, SEC14L2, C22orf6, KIAA1186, KIAA1658|
|Target/Specificity||This SEC14L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-69 amino acids from the N-terminal region of human SEC14L2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SEC14L2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C22orf6, KIAA1186, KIAA1658|
|Function||Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.|
|Cellular Location||Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha- tocopherol|
|Tissue Location||Widely expressed. Strong expression in liver, brain and prostate.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)
Wang, X., et al. Cancer Invest. 27(10):971-977(2009)
Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870(2009)
Johnykutty, S., et al. Mod. Pathol. 22(6):770-775(2009)
Wright, M.E., et al. Cancer Res. 69(4):1429-1438(2009)
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