|Application ||WB, E|
|Other Accession||NP_671702.1, NP_671701.1|
|Calculated MW||16829 Da|
|Antigen Region||62-90 aa|
|Other Names||Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical], Diadenosine 5', 5'''-P1, P4-tetraphosphate asymmetrical hydrolase, Ap4A hydrolase, Ap4Aase, Diadenosine tetraphosphatase, Nucleoside diphosphate-linked moiety X motif 2, Nudix motif 2, NUDT2, APAH1|
|Target/Specificity||This NUDT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-90 amino acids from the Central region of human NUDT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NUDT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and three transcript variants, all encoding the same protein, have been identified.
Vasilenko, N., et al. Virol. J. 7, 31 (2010) :
Swarbrick, J.D., et al. J. Biol. Chem. 280(9):8471-8481(2005)
Swarbrick, J.D., et al. J. Biomol. NMR 31(2):181-182(2005)
Pitcher, W.H. III, et al. Antiviral Res. 58(3):227-233(2003)
Guranowski, A., et al. Acta Biochim. Pol. 50(1):123-130(2003)
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