|Application ||WB, E|
|Other Accession||Q498M4, P61965, Q2KIG2, NP_060058.1, NP_438172.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||36588 Da|
|Antigen Region||12-40 aa|
|Other Names||WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, WDR5, BIG3|
|Target/Specificity||This WDR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human WDR5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WDR5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
Davis, O.S., et al. Behav. Genet. 40(6):759-767(2010)
Yates, J.A., et al. FEBS Lett. 584(4):689-693(2010)
Cai, Y., et al. J. Biol. Chem. 285(7):4268-4272(2010)
Wang, Y.Y., et al. Proc. Natl. Acad. Sci. U.S.A. 107(2):815-820(2010)
Patel, A., et al. J. Biol. Chem. 284(36):24242-24256(2009)
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