|Application ||WB, E|
|Other Accession||Q498M4, P61965, Q2KIG2, NP_060058.1, NP_438172.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||36588 Da|
|Antigen Region||12-40 aa|
|Other Names||WD repeat-containing protein 5, BMP2-induced 3-kb gene protein, WDR5, BIG3|
|Target/Specificity||This WDR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human WDR5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WDR5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
Davis, O.S., et al. Behav. Genet. 40(6):759-767(2010)
Yates, J.A., et al. FEBS Lett. 584(4):689-693(2010)
Cai, Y., et al. J. Biol. Chem. 285(7):4268-4272(2010)
Wang, Y.Y., et al. Proc. Natl. Acad. Sci. U.S.A. 107(2):815-820(2010)
Patel, A., et al. J. Biol. Chem. 284(36):24242-24256(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.