TAX1BP1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q86VP1 |
Other Accession | NP_006015.4, NP_001073333.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 90877 Da |
Antigen Region | 400-429 aa |
Gene ID | 8887 |
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Other Names | Tax1-binding protein 1, TRAF6-binding protein, TAX1BP1, T6BP |
Target/Specificity | This TAX1BP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-429 amino acids from the Central region of human TAX1BP1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TAX1BP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TAX1BP1 |
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Synonyms | T6BP |
Function | Ubiquitin-binding adapter that participates in inflammatory, antiviral and innate immune processes as well as selective autophagy regulation (PubMed:30459273, PubMed:29940186, PubMed:30909570). Plays a key role in the negative regulation of NF-kappa-B and IRF3 signalings by acting as an adapter for the ubiquitin-editing enzyme A20/TNFAIP3 to bind and inactivate its substrates (PubMed:17703191). Disrupts the interactions between the E3 ubiquitin ligase TRAF3 and TBK1/IKBKE to attenuate 'Lys63'-linked polyubiquitination of TBK1 and thereby IFN- beta production (PubMed:21885437). Recruits also A20/TNFAIP3 to ubiquitinated signaling proteins TRAF6 and RIPK1, leading to their deubiquitination and disruption of IL-1 and TNF-induced NF-kappa-B signaling pathways (PubMed:17703191). Inhibits virus-induced apoptosis by inducing the 'Lys-48'-linked polyubiquitination and degradation of MAVS via recruitment of the E3 ligase ITCH, thereby attenuating MAVS- mediated apoptosis signaling (PubMed:27736772). As a macroautophagy/autophagy receptor, facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis (PubMed:26451915). Upon NBR1 recruitment to the SQSTM1- ubiquitin condensates, acts as the major recruiter of RB1CC1 to these ubiquitin condensates to promote their autophagic degradation (PubMed:33226137, PubMed:34471133). |
Cellular Location | Cytoplasm. Mitochondrion. Preautophagosomal structure Cytoplasmic vesicle, autophagosome |
Tissue Location | Expressed in all tissues tested. |
Provided below are standard protocols that you may find useful for product applications.
Background
The HTLV-1 Tax protein transcriptionally activates the HTLV-1 promoter. Tax also binds to and stimulates the expression of cellular genes, including transcription factors and other proteins (Gachon et al., 1998 [PubMed 9733879]).
References
Parvatiyar, K., et al. J. Biol. Chem. 285(20):14999-15009(2010)
Ruiz, M.T., et al. Braz J Otorhinolaryngol 76(2):193-198(2010)
Shembade, N., et al. Science 327(5969):1135-1139(2010)
Dieguez-Gonzalez, R., et al. Ann. Rheum. Dis. 68(4):579-583(2009)
Shembade, N., et al. EMBO J. 28(5):513-522(2009)
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