- CITATIONS: 1
|Application ||WB, E|
|Other Accession||NP_006015.4, NP_001073333.1|
|Calculated MW||90877 Da|
|Antigen Region||400-429 aa|
|Other Names||Tax1-binding protein 1, TRAF6-binding protein, TAX1BP1, T6BP|
|Target/Specificity||This TAX1BP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-429 amino acids from the Central region of human TAX1BP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAX1BP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.|
|Tissue Location||Expressed in all tissues tested.|
Provided below are standard protocols that you may find useful for product applications.
The HTLV-1 Tax protein transcriptionally activates the HTLV-1 promoter. Tax also binds to and stimulates the expression of cellular genes, including transcription factors and other proteins (Gachon et al., 1998 [PubMed 9733879]).
Parvatiyar, K., et al. J. Biol. Chem. 285(20):14999-15009(2010)
Ruiz, M.T., et al. Braz J Otorhinolaryngol 76(2):193-198(2010)
Shembade, N., et al. Science 327(5969):1135-1139(2010)
Dieguez-Gonzalez, R., et al. Ann. Rheum. Dis. 68(4):579-583(2009)
Shembade, N., et al. EMBO J. 28(5):513-522(2009)
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