FDXR Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P22570 |
Other Accession | NP_077728.2, NP_004101.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 53837 Da |
Antigen Region | 459-487 aa |
Gene ID | 2232 |
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Other Names | NADPH:adrenodoxin oxidoreductase, mitochondrial, AR, Adrenodoxin reductase, Ferredoxin--NADP(+) reductase, Ferredoxin reductase, FDXR, ADXR |
Target/Specificity | This FDXR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 459-487 amino acids from the C-terminal region of human FDXR. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | FDXR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | FDXR (HGNC:3642) |
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Synonyms | ADXR |
Function | Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C- 27 hydroxylation in the liver. |
Cellular Location | Mitochondrion inner membrane {ECO:0000250|UniProtKB:P48360}; Peripheral membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants of this gene have been described although the full-length nature of only two that encode different isoforms have been determined.
References
Trapasso, F., et al. J. Biol. Chem. 283(20):13736-13744(2008)
Araya, Z., et al. Biochim. Biophys. Acta 1632 (1-3), 40-47 (2003) :
Thiboutot, D., et al. J. Invest. Dermatol. 120(6):905-914(2003)
Liu, G., et al. Oncogene 21(47):7195-7204(2002)
Coghlan, V.M., et al. J. Biol. Chem. 266(28):18606-18612(1991)
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