|Application ||WB, E|
|Other Accession||NP_077728.2, NP_004101.2|
|Calculated MW||53837 Da|
|Antigen Region||459-487 aa|
|Other Names||NADPH:adrenodoxin oxidoreductase, mitochondrial, AR, Adrenodoxin reductase, Ferredoxin--NADP(+) reductase, Ferredoxin reductase, FDXR, ADXR|
|Target/Specificity||This FDXR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 459-487 amino acids from the C-terminal region of human FDXR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FDXR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.|
|Cellular Location||Mitochondrion matrix.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants of this gene have been described although the full-length nature of only two that encode different isoforms have been determined.
Trapasso, F., et al. J. Biol. Chem. 283(20):13736-13744(2008)
Araya, Z., et al. Biochim. Biophys. Acta 1632 (1-3), 40-47 (2003) :
Thiboutot, D., et al. J. Invest. Dermatol. 120(6):905-914(2003)
Liu, G., et al. Oncogene 21(47):7195-7204(2002)
Coghlan, V.M., et al. J. Biol. Chem. 266(28):18606-18612(1991)
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