|Application ||WB, E|
|Other Accession||NP_003186.1, NP_942016.1|
|Calculated MW||33601 Da|
|Antigen Region||86-115 aa|
|Other Names||Transcription elongation factor A protein 2, Testis-specific S-II, Transcription elongation factor S-II protein 2, Transcription elongation factor TFIISl, TCEA2|
|Target/Specificity||This TCEA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-115 amino acids from the Central region of human TCEA2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TCEA2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|
|Tissue Location||Testis and ovary specific.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene.
Kuraoka, I., et al. DNA Repair (Amst.) 6(6):841-851(2007)
Palangat, M., et al. Proc. Natl. Acad. Sci. U.S.A. 102(42):15036-15041(2005)
Stelzl, U., et al. Cell 122(6):957-968(2005)
Nakata, A., et al. Genes Cells 9(11):1125-1135(2004)
Tamura, K., et al. Biochem. Biophys. Res. Commun. 309(1):189-195(2003)
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