|Application ||WB, E|
|Calculated MW||16609 Da|
|Antigen Region||66-95 aa|
|Other Names||C-C motif chemokine 25, Chemokine TECK, Small-inducible cytokine A25, Thymus-expressed chemokine, CCL25, SCYA25, TECK|
|Target/Specificity||This CCL25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-95 amino acids from the Central region of human CCL25.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CCL25 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.|
|Tissue Location||Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9.
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Wang, Y., et al. Cell. Mol. Immunol. 7(1):51-60(2010)
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Siezen, C.L., et al. Pediatr. Infect. Dis. J. 28(4):333-335(2009)
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