|Application ||WB, E|
|Calculated MW||42742 Da|
|Antigen Region||168-196 aa|
|Other Names||Leukocyte elastase inhibitor, LEI, Monocyte/neutrophil elastase inhibitor, EI, M/NEI, Peptidase inhibitor 2, PI-2, Serpin B1, SERPINB1, ELANH2, MNEI, PI2|
|Target/Specificity||This SERPINB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-196 amino acids from the Central region of human SERPINB1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SERPINB1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ELANH2, MNEI, PI2|
|Function||Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H.|
|Cellular Location||Cytoplasm. Cytoplasmic granule|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
SERPINB1 regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3.
Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Ahmed, M., et al. J. Proteome Res. 4(3):931-940(2005)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)
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