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SERPINB1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P30740 |
| Other Accession | NP_109591.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 42742 Da |
| Antigen Region | 168-196 aa |
| Gene ID | 1992 |
|---|---|
| Other Names | Leukocyte elastase inhibitor, LEI, Monocyte/neutrophil elastase inhibitor, EI, M/NEI, Peptidase inhibitor 2, PI-2, Serpin B1, SERPINB1, ELANH2, MNEI, PI2 |
| Target/Specificity | This SERPINB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-196 amino acids from the Central region of human SERPINB1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SERPINB1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SERPINB1 |
|---|---|
| Synonyms | ELANH2, MNEI, PI2 |
| Function | Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3 (PubMed:11747453, PubMed:30692621). Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity (PubMed:23269243). During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). When secreted, promotes the proliferation of beta-cells via its protease inhibitory function (PubMed:26701651). |
| Cellular Location | Secreted. Cytoplasm. Cytolytic granule. Early endosome |
| Tissue Location | In human bone marrow, present in all CD45+ populations. Expression levels are highest in the neutrophil lineage, intermediate in monocytic, and lowest in lymphocytic lineage. Within the neutrophil lineage, expression is highest in promyelocytes |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SERPINB1 regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3.
References
Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)
Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
Ahmed, M., et al. J. Proteome Res. 4(3):931-940(2005)
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Gevaert, K., et al. Nat. Biotechnol. 21(5):566-569(2003)
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