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>   home   >   Products   >   Primary Antibodies   >   NR2C1 Antibody (C-term)   

NR2C1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NR2C1 Antibody (C-term) AP16146B
    NR2C1 Antibody (C-term) (Cat. #AP16146b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the NR2C1 antibody detected the NR2C1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P13056
Other Accession Q95K90, A0JNE3, NP_001027458.1, NP_001120834.1
Reactivity Human
Predicted Bovine, Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 67315 Da
Antigen Region 516-545 aa
Additional Information
Gene ID 7181
Other Names Nuclear receptor subfamily 2 group C member 1, Orphan nuclear receptor TR2, Testicular receptor 2, NR2C1, TR2
Target/Specificity This NR2C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 516-545 amino acids from the C-terminal region of human NR2C1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNR2C1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NR2C1
Synonyms TR2
Function Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid- regulated preadipocyte proliferation.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. Nucleus, PML body. Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation
Citations (0)

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This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.


Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lin, Y.L., et al. Biochem. Biophys. Res. Commun. 350(2):430-436(2006)
Li, G., et al. Biochem. Biophys. Res. Commun. 310(2):384-390(2003)
Mu, X., et al. Prostate 57(2):129-133(2003)
Franco, P.J., et al. Mol. Endocrinol. 15(8):1318-1328(2001)

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$ 295.00
$ 99.00
Cat# AP16146B
(40 western blots)
Availability: In Stock
Bulk Size
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