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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MAFA Antibody (C-term)   

MAFA Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MAFA Antibody (C-term) AP16148b
    MAFA Antibody (C-term) (Cat. #AP16148b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the MAFA antibody detected the MAFA protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8NHW3
Other Accession Q8CF90, NP_963883.2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 36982 Da
Antigen Region 286-315 aa
Additional Information
Gene ID 389692
Other Names Transcription factor MafA, Pancreatic beta-cell-specific transcriptional activator, Transcription factor RIPE3b1, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A, MAFA
Target/Specificity This MAFA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-315 amino acids from the C-terminal region of human MAFA.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMAFA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:11416124, ECO:0000269|PubMed:12368292}. Note=Detected in nuclei of pancreas islet beta cells.
Research Areas
Citations (0)

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MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).


Lecoin, L., et al. Dev Neurobiol 70(7):485-497(2010)
Guo, S., et al. J. Biol. Chem. 285(17):12655-12661(2010)
Kondo, T., et al. Mol. Endocrinol. 23(8):1281-1290(2009)
Kaneto, H., et al. Adv. Drug Deliv. Rev. 61 (7-8), 489-496 (2009) :
Garin, I., et al. Diabet. Med. 26(7):746-748(2009)

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Cat# AP16148b
(40 western blots)
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