|Application ||WB, E|
|Other Accession||P19945, Q29214, P14869, Q9PV90, Q95140, Q8NHW5, NP_000993.1, NP_444505.1|
|Predicted||Bovine, Zebrafish, Mouse, Pig, Rat|
|Calculated MW||34274 Da|
|Antigen Region||1-30 aa|
|Other Names||60S acidic ribosomal protein P0, 60S ribosomal protein L10E, RPLP0|
|Target/Specificity||This RPLP0 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human RPLP0.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RPLP0 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ribosomal protein P0 is the functional equivalent of E.coli protein L10.|
|Cellular Location||Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs|
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Provided below are standard protocols that you may find useful for product applications.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Vascotto, C., et al. Mol. Cell. Biol. 29(7):1834-1854(2009)
Rinne, T., et al. Hum. Mol. Genet. 17(13):1968-1977(2008)
Chang, T.W., et al. Oncogene 27(3):332-338(2008)
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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