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> home > Products > Primary Antibodies > Antibody Collections > Anti-Wnt-Pathway (plus Lgr5) Antibodies > SMARCD1 Antibody (C-term)
SMARCD1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96GM5 |
| Other Accession | Q61466, Q2TBN1, NP_003067.3, NP_620710.2 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 58233 Da |
| Antigen Region | 431-459 aa |
| Gene ID | 6602 |
|---|---|
| Other Names | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1, 60 kDa BRG-1/Brm-associated factor subunit A, BRG1-associated factor 60A, BAF60A, SWI/SNF complex 60 kDa subunit, SMARCD1 {ECO:0000312|EMBL:AAD233901} |
| Target/Specificity | This SMARCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 431-459 amino acids from the C-terminal region of human SMARCD1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SMARCD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SMARCD1 {ECO:0000312|EMBL:AAD23390.1} |
|---|---|
| Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:8804307, PubMed:29374058). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer (PubMed:14698202). Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (PubMed:12917342). Interacts with AKIRIN2 (By similarity). |
| Cellular Location | Nucleus {ECO:0000269|PubMed:8804307, ECO:0000305} |
| Tissue Location | Expressed in all tissues tested, including brain, heart, kidney, liver, lung, muscle, pancreas and placenta |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Two transcript variants encoding different isoforms have been found for this gene.
References
van de Wijngaart, D.J., et al. Mol. Endocrinol. 23(11):1776-1786(2009)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Assmann, E.M., et al. J. Biol. Chem. 281(15):9869-9881(2006)
Hsiao, P.W., et al. Mol. Cell. Biol. 23(17):6210-6220(2003)
Kitagawa, H., et al. Cell 113(7):905-917(2003)
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$ 182.50
$ 70.00
Cat# AP16186b
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