|Application ||WB, E|
|Calculated MW||53498 Da|
|Antigen Region||161-190 aa|
|Other Names||Complement C1r subcomponent-like protein, C1r-LP, C1r-like protein, 3421-, C1r-like serine protease analog protein, CLSPa, C1RL, C1RL1, C1RLP, CLSPA|
|Target/Specificity||This C1RL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from the Central region of human C1RL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||C1RL Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C1RL1, C1RLP, CLSPA|
|Function||Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.|
|Tissue Location||Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV- 3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U-251MG (glioma) or A-549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level)|
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C1RL mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.
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