|Application ||WB, E|
|Calculated MW||200552 Da|
|Antigen Region||1087-1115 aa|
|Other Names||E3 ubiquitin-protein ligase listerin, 632-, RING finger protein 160, Zinc finger protein 294, LTN1, C21orf10, C21orf98, KIAA0714, RNF160, ZNF294|
|Target/Specificity||This RNF160 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1087-1115 amino acids from the Central region of human RNF160.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RNF160 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C21orf10, C21orf98, KIAA0714, RNF160, ZN|
|Function||E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM].
Bengtson, M.H., et al. Nature 467(7314):470-473(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Chu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(7):2097-2103(2009)
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