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RNF160 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O94822 |
| Other Accession | NP_056380.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 200552 Da |
| Antigen Region | 1087-1115 aa |
| Gene ID | 26046 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase listerin, 632-, RING finger protein 160, Zinc finger protein 294, LTN1, C21orf10, C21orf98, KIAA0714, RNF160, ZNF294 |
| Target/Specificity | This RNF160 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1087-1115 amino acids from the Central region of human RNF160. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RNF160 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LTN1 |
|---|---|
| Synonyms | C21orf10, C21orf98, KIAA0714, RNF160, ZN |
| Function | E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875, PubMed:28757607). Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains (PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity). |
| Cellular Location | Cytoplasm, cytosol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM].
References
Bengtson, M.H., et al. Nature 467(7314):470-473(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Chu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(7):2097-2103(2009)
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