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DNAH2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9P225 |
| Other Accession | NP_065928.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 507698 Da |
| Antigen Region | 440-468 aa |
| Gene ID | 146754 |
|---|---|
| Other Names | Dynein heavy chain 2, axonemal, Axonemal beta dynein heavy chain 2, Ciliary dynein heavy chain 2, Dynein heavy chain domain-containing protein 3, DNAH2, DNAHC2, DNHD3, KIAA1503 |
| Target/Specificity | This DNAH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 440-468 amino acids from the N-terminal region of human DNAH2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DNAH2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DNAH2 (HGNC:2948) |
|---|---|
| Synonyms | DNAHC2, DNHD3, KIAA1503 |
| Function | As part of the axonemal inner dynein arm complex plays a central role in ciliary beat (PubMed:30811583). Expressed in sperm flagellum, it is required for sperm motility (PubMed:30811583). Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending (PubMed:30811583). |
| Cellular Location | Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:P0C6F1}. Cytoplasm, cytoskeleton, flagellum axoneme |
| Tissue Location | Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung Expressed in spermatozoa (at protein level) (PubMed:31178125) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 [PubMed 9256245]).
References
Barrett, J.C., et al. Nat. Genet. (2009) In press :
Wistow, G., et al. Mol. Vis. 8, 196-204 (2002) :
Chapelin, C., et al. FEBS Lett. 412(2):325-330(1997)
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