|Application ||WB, E|
|Calculated MW||507698 Da|
|Antigen Region||440-468 aa|
|Other Names||Dynein heavy chain 2, axonemal, Axonemal beta dynein heavy chain 2, Ciliary dynein heavy chain 2, Dynein heavy chain domain-containing protein 3, DNAH2, DNAHC2, DNHD3, KIAA1503|
|Target/Specificity||This DNAH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 440-468 amino acids from the N-terminal region of human DNAH2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DNAH2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DNAHC2, DNHD3, KIAA1503|
|Function||Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton, cilium axoneme|
|Tissue Location||Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in lung|
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Provided below are standard protocols that you may find useful for product applications.
Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 [PubMed 9256245]).
Barrett, J.C., et al. Nat. Genet. (2009) In press :
Wistow, G., et al. Mol. Vis. 8, 196-204 (2002) :
Chapelin, C., et al. FEBS Lett. 412(2):325-330(1997)
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