|Application ||WB, E|
|Other Accession||NP_060217.1, NP_078944.2, NP_060448.1|
|Calculated MW||269458 Da|
|Antigen Region||445-474 aa|
|Other Names||Ankyrin repeat and KH domain-containing protein 1, HIV-1 Vpr-binding ankyrin repeat protein, Multiple ankyrin repeats single KH domain, hMASK, ANKHD1, KIAA1085, MASK, VBARP|
|Target/Specificity||This ANKHD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 amino acids from the N-terminal region of human ANKHD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ANKHD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1085, MASK, VBARP|
|Function||May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases.|
|Tissue Location||Ubiquitous with high expression in cervix, spleen and brain. Expressed in hematopoietic cells with increased expression in leukemia cells. Isoform 2 is highly expressed in spleen with almost no expression in muscle and brain|
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Provided below are standard protocols that you may find useful for product applications.
The ANKHD1-EIF4EBP3 mRNA is an infrequent but naturally occurring readthrough transcript of the neighboring ANKHD1 and EIF4EBP3 genes. This readthrough transcript encodes a protein composed mostly of the multiple ankyrin repeats, single KH-domain protein, with its C-terminus encoded in a different reading frame from the shared portion of the EIF4EBP3 gene. The significance of this readthrough mRNA and the function of its protein product have not yet been determined.
Prakash, T., et al. PLoS ONE 5 (10), E13284 (2010) :
Santos Duarte Ada, S., et al. Gene 363, 113-122 (2005) :
Poulin, F., et al. J. Biol. Chem. 278(52):52290-52297(2003)
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