|Application ||WB, E|
|Other Accession||Q05695, P11627, NP_001137435.1|
|Calculated MW||140003 Da|
|Antigen Region||1154-1182 aa|
|Other Names||Neural cell adhesion molecule L1, N-CAM-L1, NCAM-L1, CD171, L1CAM, CAML1, MIC5|
|Target/Specificity||This L1CAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1154-1182 amino acids from the C-terminal region of human L1CAM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||L1CAM Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
Schafer, M.K., et al. FEBS Lett. 584(21):4475-4480(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Bertolin, C., et al. J. Neurol. Sci. 294 (1-2), 124-126 (2010) :
Schafer, M.K., et al. Cell. Mol. Life Sci. 67(14):2425-2437(2010)
Gavert, N., et al. J. Cell. Sci. 123 (PT 12), 2135-2143 (2010) :
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