|Application ||WB, E|
|Calculated MW||39295 Da|
|Antigen Region||287-316 aa|
|Other Names||Hydroxycarboxylic acid receptor 1, G-protein coupled receptor 104, G-protein coupled receptor 81, HCAR1, GPR104, GPR81, HCA1|
|Target/Specificity||This GPR81 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-316 amino acids from the C-terminal region of human GPR81.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPR81 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR104, GPR81, HCA1|
|Function||Acts as a receptor for L-lactate and mediates its anti- lipolytic effect through a G(i)-protein-mediated pathway.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumbens and hippocampus.|
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Provided below are standard protocols that you may find useful for product applications.
G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Jeninga, E.H., et al. J. Biol. Chem. 284(39):26385-26393(2009)
Liu, C., et al. J. Biol. Chem. 284(5):2811-2822(2009)
Cai, T.Q., et al. Biochem. Biophys. Res. Commun. 377(3):987-991(2008)
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