|Application ||WB, E|
|Other Accession||P54825, P56563, P20274, NP_085915.2, NP_001155220.1|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||19674 Da|
|Antigen Region||110-137 aa|
|Other Names||Lens fiber membrane intrinsic protein, MP18, MP19, MP20, LIM2|
|Target/Specificity||This LIM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 110-137 amino acids from the C-terminal region of human LIM2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LIM2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Eye lens specific.|
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Provided below are standard protocols that you may find useful for product applications.
LIM2 is an eye lens-specific protein found at the junctions of lens fiber cells, where it may contribute to cell junctional organization. It acts as a receptor for calmodulin, and may play an important role in both lens development and cataractogenesis. Mutations in this gene have been associated with cataract formation.
Ponnam, S.P., et al. Mol. Vis. 14, 1204-1208 (2008) :
Hsu, H., et al. Sheng Wu Gong Cheng Xue Bao 20(4):507-515(2004)
Wistow, G., et al. Mol. Vis. 8, 171-184 (2002) :
Wistow, G., et al. Mol. Vis. 8, 185-195 (2002) :
Pras, E., et al. Am. J. Hum. Genet. 70(5):1363-1367(2002)
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