|Application ||WB, E|
|Calculated MW||106834 Da|
|Antigen Region||395-424 aa|
|Other Names||Centromere protein C, CENP-C, Centromere autoantigen C, Centromere protein C 1, CENP-C 1, Interphase centromere complex protein 7, CENPC, CENPC1, ICEN7|
|Target/Specificity||This CENPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-424 amino acids from the Central region of human CENPC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CENPC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.|
|Cellular Location||Nucleus. Chromosome, centromere, kinetochore Note=Localizes exclusively in the kinetochore domain of centromeres.|
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Provided below are standard protocols that you may find useful for product applications.
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq].
Gopalakrishnan, S., et al. Hum. Mol. Genet. 18(17):3178-3193(2009)
Yosifova, A., et al. J Affect Disord 117 (1-2), 87-97 (2009) :
Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)
Trazzi, S., et al. PLoS ONE 4 (6), E5832 (2009) :
Seshadri, S., et al. BMC Med. Genet. 8 SUPPL 1, S15 (2007) :
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