|Application ||WB, E|
|Calculated MW||20165 Da|
|Antigen Region||63-92 aa|
|Other Names||Tumor necrosis factor receptor superfamily member 17, B-cell maturation protein, CD269, TNFRSF17, BCM, BCMA|
|Target/Specificity||This TNFRSF17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-92 amino acids from the Central region of human TNFRSF17.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TNFRSF17 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.|
|Cellular Location||Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures|
|Tissue Location||Expressed in mature B-cells, but not in T- cells or monocytes|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
Chae, S.C., et al. Mol. Cells 29(1):21-28(2010)
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Barone, F., et al. Mucosal Immunol 2(6):495-503(2009)
Newton-Cheh, C., et al. Nat. Genet. 41(4):399-406(2009)
Li, H., et al. PLoS ONE 4 (7), E6410 (2009) :
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