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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   SIGLEC6 Antibody (N-term)   

SIGLEC6 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SIGLEC6 Antibody (N-term) AP1624a
    Western blot analysis of SIGLEC6 Antibody (N-term) (Cat.#AP1624a) in NCI-H460 cell line lysates (35ug/lane). SIGLEC6 (arrow) was detected using the purified Pab.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O43699
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 49913 Da
Antigen Region 10-40 aa
Additional Information
Gene ID 946
Other Names Sialic acid-binding Ig-like lectin 6, Siglec-6, CD33 antigen-like 1, CDw327, Obesity-binding protein 1, OB-BP1, CD327, SIGLEC6, CD33L, CD33L1, OBBP1
Target/Specificity This SIGLEC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-40 amino acids from the N-terminal region of human SIGLEC6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSIGLEC6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIGLEC6
Synonyms CD33L, CD33L1, OBBP1
Function Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine
Research Areas
Citations (0)

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Background

SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.

References

Patel, N., et al., J. Biol. Chem. 274(32):22729-22738 (1999).
Takei, Y., et al., Cytogenet. Cell Genet. 78 (3-4), 295-300 (1997).
Patel, N., et al., J. Biol. Chem. 274, 28058-28058 (1999).

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$ 295.00
$ 99.00
Cat# AP1624a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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