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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   SIGLEC6 Antibody (C-term)   

SIGLEC6 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • IHC-P - SIGLEC6 Antibody (C-term) AP1624b
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
  • WB - SIGLEC6 Antibody (C-term) AP1624b
    The anti-Siglec6 C-term Pab (Cat. #AP1624b) is used in Western blot to detect Siglec6 in mouse spleen tissue lysate.
  • WB - SIGLEC6 Antibody (C-term) AP1624b
    SIGLEC6 Antibody (Cat. #AP1624b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SIGLEC6 antibody detected the SIGLEC6 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43699
Other Accession NP_001236
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 49913 Da
Antigen Region 381-412 aa
Additional Information
Gene ID 946
Other Names Sialic acid-binding Ig-like lectin 6, Siglec-6, CD33 antigen-like 1, CDw327, Obesity-binding protein 1, OB-BP1, CD327, SIGLEC6, CD33L, CD33L1, OBBP1
Target/Specificity This SIGLEC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-412 amino acids from the C-terminal region of human SIGLEC6.
Dilution IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSIGLEC6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CD33L, CD33L1, OBBP1
Function Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine
Research Areas
Citations (0)

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SIGLEC6 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells by binding to alpha2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. SIGLEC6, which interacts with LEP, is expressed at high levels in placenta (cyto-and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. It contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in downmodulation of cellular responses. The phosphorylated ITIM motif binds to the SH2 domain of PTPN6/SHP-1. The gene for SIGLEC6 belongs to the immunoglobulin superfamily.


Patel, N., et al., J. Biol. Chem. 274(32):22729-22738 (1999).
Takei, Y., et al., Cytogenet. Cell Genet. 78 (3-4), 295-300 (1997).
Patel, N., et al., J. Biol. Chem. 274, 28058-28058 (1999).

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$ 295.00
$ 99.00
Cat# AP1624b
(40 western blots)
Availability: In Stock
Bulk Size
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