STX12 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q86Y82 |
Other Accession | G3V7P1, Q9ER00, NP_803173.1 |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 31642 Da |
Antigen Region | 224-251 aa |
Gene ID | 23673 |
---|---|
Other Names | Syntaxin-12, STX12 |
Target/Specificity | This STX12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-251 amino acids from the C-terminal region of human STX12. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | STX12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | STX12 |
---|---|
Function | SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. |
Cellular Location | Endosome membrane {ECO:0000250|UniProtKB:G3V7P1}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:G3V7P1} Golgi apparatus membrane {ECO:0000250|UniProtKB:G3V7P1}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:G3V7P1}. Endomembrane system {ECO:0000250|UniProtKB:G3V7P1}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:G3V7P1}; Cytoplasmic side {ECO:0000250|UniProtKB:G3V7P1}. Early endosome membrane {ECO:0000250|UniProtKB:G3V7P1}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:G3V7P1}. Recycling endosome membrane {ECO:0000250|UniProtKB:G3V7P1}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:G3V7P1} |
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Provided below are standard protocols that you may find useful for product applications.
Background
SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network (By similarity).
References
Kean, M.J., et al. J. Cell. Sci. 122 (PT 22), 4089-4098 (2009) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Bared, S.M., et al. Mol. Biol. Cell 15(12):5399-5407(2004)
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