|Application ||WB, E|
|Other Accession||Q05438, NP_031586.1|
|Calculated MW||56944 Da|
|Antigen Region||133-160 aa|
|Other Names||Bone morphogenetic protein receptor type-1B, BMP type-1B receptor, BMPR-1B, Activin receptor-like kinase 6, ALK-6, Serine/threonine-protein kinase receptor R6, SKR6, CDw293, Bmpr1b, Acvrlk6|
|Target/Specificity||This Mouse Bmpr1b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-160 amino acids from the Central region of mouse Bmpr1b.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Bmpr1b Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1. Receptor for GDF5 (PubMed:26105076, PubMed:19229295). Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149).|
|Cellular Location||Cell membrane. Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1.
Chiang, P.M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(37):16320-16324(2010)
Witte, F., et al. Proc. Natl. Acad. Sci. U.S.A. 107(32):14211-14216(2010)
Libusova, L., et al. Development 137(14):2297-2305(2010)
Suzuki, Y., et al. J. Cell. Sci. 123 (PT 10), 1684-1692 (2010) :
Caronia, G., et al. J. Neurosci. 30(18):6291-6301(2010)
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