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DCT Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - DCT Antibody (Center) AP16267c
    DCT Antibody (Center) (Cat. #AP16267c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the DCT antibody detected the DCT protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P40126
Other Accession NP_001913.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 59145 Da
Antigen Region 286-314 aa
Additional Information
Gene ID 1638
Other Names L-dopachrome tautomerase, DCT, DT, L-dopachrome Delta-isomerase, Tyrosinase-related protein 2, TRP-2, TRP2, DCT, TYRP2
Target/Specificity This DCT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-314 amino acids from the Central region of human DCT.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDCT Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCT
Synonyms TYRP2
Function Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:8306979). Involved in regulating eumelanin and phaeomelanin levels.
Cellular Location Melanosome membrane; Single-pass type I membrane protein. Melanosome {ECO:0000250|UniProtKB:P29812}. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38 {ECO:0000250|UniProtKB:P29812}
Research Areas
Citations (0)

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Background

DCT is involved in regulating eumelanin and phaeomelanin levels.

References

Sendoel, A., et al. Nature 465(7298):577-583(2010)
Khong, H.T., et al. J. Immunol. 168(2):951-956(2002)
Sugimoto, H., et al. Biochemistry 38(11):3268-3279(1999)
Nishihira, J., et al. Biochem. Biophys. Res. Commun. 243(2):538-544(1998)
Sugimoto, H., et al. J. Struct. Biol. 120(1):105-108(1997)

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$ 295.00
$ 99.00
Cat# AP16267c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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