|Application ||WB, E|
|Other Accession||F1SRI0, Q9CQP2, Q08CN0, Q5ZKP4, Q3T0F2, P0DI82|
|Predicted||Bovine, Chicken, Zebrafish, Mouse, Pig|
|Calculated MW||16445 Da|
|Antigen Region||11-39 aa|
|Other Names||Trafficking protein particle complex subunit 2, Sedlin, TRAPPC2, SEDL|
|Target/Specificity||This TRAPPC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-39 amino acids from the N-terminal region of human TRAPPC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRAPPC2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic reticulum to Golgi.|
|Cellular Location||Cytoplasm, perinuclear region. Endoplasmic reticulum-Golgi intermediate compartment. Nucleus Cytoplasm. Note=Localized in perinuclear granular structures.|
|Tissue Location||Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, fetal cartilage, fibroblasts, placenta and lymphocytes|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
TRAPPC2 is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y.
Liu, X., et al. J. Cell. Biochem. 109(6):1129-1133(2010)
Jeyabalan, J., et al. PLoS ONE 5 (5), E10646 (2010) :
Xia, X.Y., et al. Clin. Chim. Acta 410 (1-2), 39-42 (2009) :
Guo, H., et al. J. Genet. 88(1):87-91(2009)
Xiong, F., et al. Eur. J. Hum. Genet. 17(4):510-516(2009)
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