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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PNPLA6 Antibody (C-term)   

PNPLA6 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PNPLA6 Antibody (C-term) AP16273b
    PNPLA6 Antibody (C-term) (Cat. #AP16273b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the PNPLA6 antibody detected the PNPLA6 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IY17
Other Accession Q3TRM4, NP_001159583.1, NP_001159585.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 149995 Da
Antigen Region 1000-1029 aa
Additional Information
Gene ID 10908
Other Names Neuropathy target esterase, Patatin-like phospholipase domain-containing protein 6, PNPLA6, NTE
Target/Specificity This PNPLA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1000-1029 amino acids from the C-terminal region of human PNPLA6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPNPLA6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NTE
Function Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.
Cellular Location Endoplasmic reticulum membrane; Single-pass type I membrane protein; Cytoplasmic side. Note=Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment
Tissue Location Expressed in brain, placenta, kidney, neuron and skeletal muscle.
Research Areas
Citations (0)

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PNPLA6 is a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].


Hein, N.D., et al. Toxicol. Lett. 199(1):1-5(2010)
Chen, J.X., et al. Pharmacol. Res. 62(3):259-264(2010)
Greiner, A.J., et al. Biochim. Biophys. Acta 1798(8):1533-1539(2010)
Hein, N.D., et al. Toxicol. Lett. 196(2):67-73(2010)
Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)

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$ 295.00
$ 99.00
Cat# AP16273b
(40 western blots)
Availability: In Stock
Bulk Size
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