PNPLA6 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8IY17 |
Other Accession | Q3TRM4, NP_001159583.1, NP_001159585.1 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 150954 Da |
Antigen Region | 1000-1029 aa |
Gene ID | 10908 |
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Other Names | Neuropathy target esterase, Patatin-like phospholipase domain-containing protein 6, PNPLA6, NTE |
Target/Specificity | This PNPLA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1000-1029 amino acids from the C-terminal region of human PNPLA6. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PNPLA6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PNPLA6 (HGNC:16268) |
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Synonyms | NTE |
Function | Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids (PubMed:11927584). Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides (PubMed:11927584). |
Cellular Location | Endoplasmic reticulum membrane; Single-pass type III membrane protein |
Tissue Location | Expressed in brain, placenta, kidney, neuron and skeletal muscle. Expressed in the developing eye, pituitary and brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
PNPLA6 is a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
References
Hein, N.D., et al. Toxicol. Lett. 199(1):1-5(2010)
Chen, J.X., et al. Pharmacol. Res. 62(3):259-264(2010)
Greiner, A.J., et al. Biochim. Biophys. Acta 1798(8):1533-1539(2010)
Hein, N.D., et al. Toxicol. Lett. 196(2):67-73(2010)
Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
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