|Application ||WB, E|
|Other Accession||Q3TRM4, NP_001159583.1, NP_001159585.1|
|Calculated MW||149995 Da|
|Antigen Region||1000-1029 aa|
|Other Names||Neuropathy target esterase, Patatin-like phospholipase domain-containing protein 6, PNPLA6, NTE|
|Target/Specificity||This PNPLA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1000-1029 amino acids from the C-terminal region of human PNPLA6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PNPLA6 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein; Cytoplasmic side. Note=Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment|
|Tissue Location||Expressed in brain, placenta, kidney, neuron and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
PNPLA6 is a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Hein, N.D., et al. Toxicol. Lett. 199(1):1-5(2010)
Chen, J.X., et al. Pharmacol. Res. 62(3):259-264(2010)
Greiner, A.J., et al. Biochim. Biophys. Acta 1798(8):1533-1539(2010)
Hein, N.D., et al. Toxicol. Lett. 196(2):67-73(2010)
Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
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