|Application ||WB, E|
|Other Accession||Q8R1X6, A0JNJ3, NP_001135766.1, NP_001135767.1|
|Calculated MW||72833 Da|
|Antigen Region||491-519 aa|
|Other Names||Spartin, Spastic paraplegia 20 protein, Trans-activated by hepatitis C virus core protein 1, SPG20, KIAA0610, TAHCCP1|
|Target/Specificity||This SPG20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 491-519 amino acids from the C-terminal region of human SPG20.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPG20 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be implicated in endosomal trafficking, or microtubule dynamics, or both.|
|Cellular Location||Cytoplasm. Note=Transiently associated with endosomes|
|Tissue Location||Ubiquitously expressed, with highest levels of expression detected in adipose tissue|
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Provided below are standard protocols that you may find useful for product applications.
SPG20 is a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).
Hooper, C., et al. BMC Biol. 8, 72 (2010) :
Milewska, M., et al. J. Neurochem. 111(4):1022-1030(2009)
Tsang, H.T., et al. Hum. Mol. Genet. 18(20):3805-3821(2009)
Edwards, T.L., et al. Biochem. J. 423(1):31-39(2009)
Eastman, S.W., et al. J. Cell Biol. 184(6):881-894(2009)
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