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>   home   >   Products   >   Primary Antibodies   >   SPG20 Antibody (C-term)   

SPG20 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SPG20 Antibody (C-term) AP16276b
    SPG20 Antibody (C-term) (Cat. #AP16276b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SPG20 antibody detected the SPG20 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8N0X7
Other Accession Q8R1X6, A0JNJ3, NP_001135766.1, NP_001135767.1
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 72833 Da
Antigen Region 491-519 aa
Additional Information
Gene ID 23111
Other Names Spartin, Spastic paraplegia 20 protein, Trans-activated by hepatitis C virus core protein 1, SPG20, KIAA0610, TAHCCP1
Target/Specificity This SPG20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 491-519 amino acids from the C-terminal region of human SPG20.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSPG20 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SPG20
Synonyms KIAA0610, TAHCCP1
Function May be implicated in endosomal trafficking, or microtubule dynamics, or both.
Cellular Location Cytoplasm. Note=Transiently associated with endosomes
Tissue Location Ubiquitously expressed, with highest levels of expression detected in adipose tissue
Citations (0)

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SPG20 is a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).


Hooper, C., et al. BMC Biol. 8, 72 (2010) :
Milewska, M., et al. J. Neurochem. 111(4):1022-1030(2009)
Tsang, H.T., et al. Hum. Mol. Genet. 18(20):3805-3821(2009)
Edwards, T.L., et al. Biochem. J. 423(1):31-39(2009)
Eastman, S.W., et al. J. Cell Biol. 184(6):881-894(2009)

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$ 295.00
$ 99.00
Cat# AP16276b
(40 western blots)
Availability: In Stock
Bulk Size
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