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BNC1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q01954 |
| Other Accession | NP_001708.3 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 110972 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 646 |
|---|---|
| Other Names | Zinc finger protein basonuclin-1, BNC1, BNC |
| Target/Specificity | This BNC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human BNC1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BNC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BNC1 |
|---|---|
| Synonyms | BNC |
| Function | Transcriptional activator (By similarity). It is likely involved in the regulation of keratinocytes terminal differentiation in squamous epithelia and hair follicles (PubMed:8034748). Required for the maintenance of spermatogenesis (By similarity). It is involved in the positive regulation of oocyte maturation, probably acting through the control of BMP15 levels and regulation of AKT signaling cascade (PubMed:30010909). May also play a role in the early development of embryos (By similarity). |
| Cellular Location | Nucleus. Cytoplasm Nucleus, nucleoplasm. Note=Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids {ECO:0000250|UniProtKB:O35914} |
| Tissue Location | In epidermis, primarily detected in cells of the basal or immediately suprabasal layers (at protein level) (PubMed:16891417). In hair follicles, mainly expressed in the outer root sheath (at protein level) (PubMed:8034748). Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart (PubMed:9687312) Expressed in the ovary, notably in oocytes (PubMed:30010909) |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. This gene seems to have multiple alternatively spliced transcript variants, but their full-length nature is not known yet. There seems to be evidence of multiple polyadenylation sites for this gene.
References
Vanhoutteghem, A., et al. Proc. Natl. Acad. Sci. U.S.A. 103(33):12423-12428(2006)
Iuchi, S., et al. Exp. Dermatol. 9(3):178-184(2000)
Tang, W., et al. Gene 237(1):35-44(1999)
Tseng, H., et al. J. Cell. Sci. 112 PT 18, 3039-3047 (1999) :
Iuchi, S., et al. Proc. Natl. Acad. Sci. U.S.A. 96(17):9628-9632(1999)
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