|Application ||WB, E|
|Calculated MW||110972 Da|
|Antigen Region||1-30 aa|
|Other Names||Zinc finger protein basonuclin-1, BNC1, BNC|
|Target/Specificity||This BNC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human BNC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BNC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Likely to be a transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. May play a role in the differentiation of spermatozoa and oocytes.|
|Cellular Location||Nucleus. Cytoplasm. Note=Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids.|
|Tissue Location||Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands, placenta, brain and heart.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. This gene seems to have multiple alternatively spliced transcript variants, but their full-length nature is not known yet. There seems to be evidence of multiple polyadenylation sites for this gene.
Vanhoutteghem, A., et al. Proc. Natl. Acad. Sci. U.S.A. 103(33):12423-12428(2006)
Iuchi, S., et al. Exp. Dermatol. 9(3):178-184(2000)
Tang, W., et al. Gene 237(1):35-44(1999)
Tseng, H., et al. J. Cell. Sci. 112 PT 18, 3039-3047 (1999) :
Iuchi, S., et al. Proc. Natl. Acad. Sci. U.S.A. 96(17):9628-9632(1999)
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