PAP2D Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q32ZL2 |
Other Accession | Q8BJ52, NP_001010861.1, NP_001032394.1 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 35427 Da |
Antigen Region | 78-106 aa |
Gene ID | 163404 |
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Other Names | Lipid phosphate phosphatase-related protein type 5, 313-, Phosphatidic acid phosphatase 2d, Plasticity-related gene 5 protein, PRG-5, LPPR5, PAP2D |
Target/Specificity | This PAP2D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78-106 amino acids from the Central region of human PAP2D. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PAP2D Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PLPPR5 (HGNC:31703) |
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Function | Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction. |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8BJ52}; Multi-pass membrane protein |
Tissue Location | Isoform 1 is expressed in brain, lung, kidney and colon. Isoform 2 is expressed in placenta, skeletal muscle and kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
PAP2D is a type 2 member of the phosphatidic acid phosphatase (PAP) family. All type 2 members of this protein family contain 6 transmembrane regions, and a consensus N-glycosylation site. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Broggini, T., et al. Mol. Biol. Cell 21(4):521-537(2010)
Sun, L., et al. Mol. Cell. Biochem. 272 (1-2), 91-96 (2005) :
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