ACPL2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8TE99 |
Other Accession | Q66H78, Q8BHA9, NP_689495.1, NP_001032249.1 |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 55240 Da |
Antigen Region | 306-335 aa |
Gene ID | 92370 |
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Other Names | 2-phosphoxylose phosphatase 1, 313-, Acid phosphatase-like protein 2, Xylosyl phosphatase {ECO:0000303|PubMed:24425863, ECO:0000312|EMBL:BAO457951}, epididymis luminal protein 124 {ECO:0000303|Ref2, ECO:0000312|EMBL:ACJ137311}, PXYLP1 (HGNC:26303) |
Target/Specificity | This ACPL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-335 amino acids from the Central region of human ACPL2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ACPL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PXYLP1 (HGNC:26303) |
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Function | Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG- protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. |
Cellular Location | Golgi apparatus membrane; Single-pass type II membrane protein. Note=Colocalizes to Golgi apparatus in a B3GAT3- dependent manner. |
Tissue Location | Widely expressed. Strongly expressed in spleen, fetal liver, moderately in placenta, pancreas, kidney, thymus and colon. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Belongs to the histidine acid phosphatase family
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Kim, J.J., et al. J. Hum. Genet. 55(1):27-31(2010)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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