|Application ||WB, E|
|Other Accession||Q9DBH5, NP_006807.1|
|Calculated MW||40229 Da|
|Antigen Region||285-314 aa|
|Other Names||Vesicular integral-membrane protein VIP36, Glycoprotein GP36b, Lectin mannose-binding 2, Vesicular integral-membrane protein 36, VIP36, LMAN2, C5orf8|
|Target/Specificity||This LMAN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-314 amino acids from the C-terminal region of human LMAN2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LMAN2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity).|
|Cellular Location||Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
LMAN2 is a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control.
Reiterer, V., et al. Traffic 11(8):1044-1055(2010)
Kottgen, A., et al. Nat. Genet. 42(5):376-384(2010)
Nawa, D., et al. Glycobiology 17(9):913-921(2007)
Kawasaki, N., et al. J. Biochem. 141(2):221-229(2007)
Kamiya, Y., et al. J. Biol. Chem. 280(44):37178-37182(2005)
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