|Application ||WB, E|
|Other Accession||Q8WP23, NP_149019.1, NP_932074.1|
|Calculated MW||31301 Da|
|Antigen Region||23-51 aa|
|Other Names||Protein boule-like, BOLL, BOULE|
|Target/Specificity||This BOLL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-51 amino acids from the N-terminal region of human BOLL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BOLL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity).|
|Tissue Location||Testis specific. Not expressed in early embryos, primordial germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis.|
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Provided below are standard protocols that you may find useful for product applications.
BOLL belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition.
Chen, P., et al. J. Androl. 31(2):163-168(2010)
Kee, K., et al. Nature 462(7270):222-225(2009)
Lin, Y.M., et al. J. Clin. Endocrinol. Metab. 94(7):2650-2657(2009)
Bilguvar, K., et al. Nat. Genet. 40(12):1472-1477(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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