|Application ||WB, E|
|Calculated MW||30366 Da|
|Antigen Region||86-114 aa|
|Other Names||GTP-binding protein Rhes, Ras homolog enriched in striatum, Tumor endothelial marker 2, RASD2, TEM2|
|Target/Specificity||This RASD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human RASD2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RASD2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.|
|Cellular Location||Cell membrane; Lipid-anchor|
|Tissue Location||Pancreatic endocrine cells (islets of Langerhans).|
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Provided below are standard protocols that you may find useful for product applications.
RASD2 is a Ras-related protein that enriched in striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades.
Hill, C., et al. Cell. Physiol. Biochem. 23 (1-3), 1-8 (2009) :
Liu, Y.L., et al. Biol. Psychiatry 64(9):789-796(2008)
Thapliyal, A., et al. Am. J. Physiol., Cell Physiol. 295 (5), C1417-C1426 (2008) :
Agretti, P., et al. J. Endocrinol. Invest. 30(4):279-284(2007)
Taylor, J.P., et al. Biochem. Biophys. Res. Commun. 349(2):809-815(2006)
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