|Application ||WB, E|
|Other Accession||NP_036451.3, NP_001092876.1|
|Calculated MW||85047 Da|
|Antigen Region||437-466 aa|
|Other Names||Zinc transporter ZIP6, Estrogen-regulated protein LIV-1, Solute carrier family 39 member 6, Zrt- and Irt-like protein 6, ZIP-6, SLC39A6, LIV1, ZIP6|
|Target/Specificity||This SLC39A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-466 amino acids from the Central region of human SLC39A6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC39A6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May act as a zinc-influx transporter.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma|
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Provided below are standard protocols that you may find useful for product applications.
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).
Lopez, V., et al. Exp. Cell Res. 316(3):366-375(2010)
Ma, X., et al. Mol. Cancer Ther. 8(11):3108-3116(2009)
Unno, J., et al. Int. J. Oncol. 35(4):813-821(2009)
French, D., et al. Blood 113(19):4512-4520(2009)
Shen, H., et al. Mol. Biol. Rep. 36(4):653-659(2009)
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