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EME2 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - EME2 Antibody (C-term) AP16348b
    EME2 Antibody (C-term) (Cat. #AP16348b) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the EME2 antibody detected the EME2 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession A4GXA9
Other Accession NP_001010865.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 41178 Da
Antigen Region 249-278 aa
Additional Information
Gene ID 197342
Other Names Probable crossover junction endonuclease EME2, 3122-, EME2
Target/Specificity This EME2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-278 amino acids from the C-terminal region of human EME2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEME2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EME2
Function Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures.
Cellular Location Nucleus.
Citations (0)
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Background

EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).

References

Ciccia, A., et al. Mol. Cell 25(3):331-343(2007)
Ciccia, A., et al. J. Biol. Chem. 278(27):25172-25178(2003)
Daniels, R.J., et al. Hum. Mol. Genet. 10(4):339-352(2001)

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$ 365.00
$ 140.00
Cat# AP16348b
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