|Application ||WB, E|
|Other Accession||P56719, P58308, NP_001517.2, O62809|
|Calculated MW||50694 Da|
|Antigen Region||275-304 aa|
|Other Names||Orexin receptor type 2, Ox-2-R, Ox2-R, Ox2R, Hypocretin receptor type 2, HCRTR2|
|Target/Specificity||This HCRTR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-304 amino acids from the Central region of human HCRTR2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HCRTR2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369).|
|Cellular Location||Cell membrane; Multi- pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Chen, J., et al. Biochem. J. 427(3):377-390(2010)
Fellay, J., et al. PLoS Genet. 5 (12), E1000791 (2009) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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