|Application ||WB, E|
|Other Accession||P61374, P61372, P53405, P50211, NP_002193.2|
|Predicted||Chicken, Zebrafish, Rat|
|Calculated MW||39036 Da|
|Antigen Region||156-185 aa|
|Other Names||Insulin gene enhancer protein ISL-1, Islet-1, ISL1|
|Target/Specificity||This ISL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the Central region of human ISL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ISL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity).|
|Tissue Location||Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain|
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Provided below are standard protocols that you may find useful for product applications.
ISL1 is a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
De Luca, A., et al. Clin. Genet. (2010) In press :
Davis, O.S., et al. Behav. Genet. (2010) In press :
Genead, R., et al. Stem Cell Res 4(1):69-76(2010)
Stevens, K.N., et al. PLoS ONE 5 (5), E10855 (2010) :
Zhang, H., et al. J. Mol. Biol. 392(3):566-577(2009)
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