|Application ||WB, E|
|Other Accession||NP_001026855.2, NP_005417.1|
|Calculated MW||125616 Da|
|Antigen Region||93-122 aa|
|Other Names||Apoptosis-stimulating of p53 protein 2, Bcl2-binding protein, Bbp, Renal carcinoma antigen NY-REN-51, Tumor suppressor p53-binding protein 2, 53BP2, p53-binding protein 2, p53BP2, TP53BP2, ASPP2, BBP|
|Target/Specificity||This TP53BP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-122 amino acids from the N-terminal region of human TP53BP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TP53BP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.|
|Cellular Location||Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42|
|Tissue Location||Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
TP53BP2 is a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Zhao, J., et al. Hepatology 51(1):142-153(2010)
Hirata, H., et al. J. Urol. 182(2):721-727(2009)
Kweekel, D.M., et al. Br. J. Cancer 101(2):357-362(2009)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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