|Application ||WB, E|
|Calculated MW||72324 Da|
|Antigen Region||450-479 aa|
|Other Names||RNA polymerase II elongation factor ELL2, ELL2|
|Target/Specificity||This ELL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 450-479 amino acids from the C-terminal region of human ELL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ELL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane- specific to secretory IgH mRNA expression.|
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Provided below are standard protocols that you may find useful for product applications.
Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Martincic, K., et al. Nat. Immunol. 10(10):1102-1109(2009) Simone, F., et al. Blood 101(6):2355-2362(2003) Simone, F., et al. Blood 98(1):201-209(2001) Shilatifard, A., et al. Proc. Natl. Acad. Sci. U.S.A. 94(8):3639-3643(1997)
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