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GRHL1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GRHL1 Antibody (Center) AP16357c
    GRHL1 Antibody (Center) (Cat. #AP16357c) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the GRHL1 antibody detected the GRHL1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NZI5
Other Accession Q921D9, NP_937825.2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 70113 Da
Antigen Region 294-322 aa
Additional Information
Gene ID 29841
Other Names Grainyhead-like protein 1 homolog, Mammalian grainyhead, NH32, Transcription factor CP2-like 2, Transcription factor LBP-32, GRHL1, LBP32, MGR, TFCP2L2
Target/Specificity This GRHL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294-322 amino acids from the Central region of human GRHL1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGRHL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRHL1 (HGNC:17923)
Function Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:12175488, PubMed:18288204). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity). Isoform 1 may function as an activator and isoform 2 as a repressor in tissues where both forms are expressed (PubMed:12175488).
Cellular Location Nucleus.
Tissue Location Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. Expressed at very low levels in non- steroidogenic cells.
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GRHL1 is a transcription factor. Isoform 1 may function as an activator and isoform 2 as a repressor in tissues where both forms are expressed. May play a role in development. May be involved in epidermal differentiation (By similarity). Binds and transactivates the EN1 promoter.

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$ 295.00
$ 99.00
Cat# AP16357c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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