|Application ||WB, E|
|Calculated MW||51400 Da|
|Antigen Region||416-443 aa|
|Other Names||DNA polymerase delta subunit 3, DNA polymerase delta subunit p66, POLD3, KIAA0039|
|Target/Specificity||This POLD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 416-443 amino acids from the C-terminal region of human POLD3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||POLD3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for optimal DNA polymerase delta activity.|
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Provided below are standard protocols that you may find useful for product applications.
The DNA polymerase delta complex is involved in DNA replication and repair, and it consists of the proliferating cell nuclear antigen (PCNA; MIM 176740), the multisubunit replication factor C (see MIM 102579), and the 4 subunit polymerase complex: POLD1 (MIM 174761), POLD2 (MIM 600815), POLD3, and POLD4 (MIM 611525) (Liu and Warbrick, 2006 [PubMed 16934752]).[supplied by OMIM].
Michiels, S., et al. Carcinogenesis 30(5):763-768(2009)
Baranovskiy, A.G., et al. Cell Cycle 7(19):3026-3036(2008)
Baranovskiy, A.G., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64 (PT 9), 822-824 (2008) :
Lemmens, L., et al. Biochem. Biophys. Res. Commun. 367(2):264-270(2008)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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