|Application ||WB, E|
|Other Accession||NP_835488.1, NP_073753.3|
|Calculated MW||92932 Da|
|Antigen Region||704-732 aa|
|Other Names||CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135 kDa protein, SIMA135, Transmembrane and associated with src kinases, CD318, CDCP1, TRASK|
|Target/Specificity||This CDCP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 704-732 amino acids from the C-terminal region of human CDCP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDCP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass membrane protein. Note=Shedding may also lead to a soluble peptide|
|Tissue Location||Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells|
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Provided below are standard protocols that you may find useful for product applications.
CDCP1 is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
He, Y., et al. J. Biol. Chem. 285(34):26162-26173(2010)
Miyazawa, Y., et al. Cancer Res. 70(12):5136-5146(2010)
Mamat, S., et al. Oncol. Rep. 23(5):1221-1227(2010)
Fukuchi, K., et al. Mol. Pharm. 7(1):245-253(2010)
Deryugina, E.I., et al. Mol. Cancer Res. 7(8):1197-1211(2009)
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