|Application ||WB, E|
|Other Accession||P97839, B1AZP2, NP_001035951.1, NP_055717.2, NP_892118.1|
|Calculated MW||108012 Da|
|Antigen Region||105-133 aa|
|Other Names||Disks large-associated protein 4, DAP-4, PSD-95/SAP90-binding protein 4, SAP90/PSD-95-associated protein 4, SAPAP-4, DLGAP4, DAP4, KIAA0964, SAPAP4|
|Target/Specificity||This DLGAP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-133 amino acids from the N-terminal region of human DLGAP4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DLGAP4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||DAP4, KIAA0964, SAPAP4|
|Function||May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.|
|Cellular Location||Membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
DLGAP4 is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Grelle, G., et al. Mol. Cell Proteomics 5(2):234-244(2006)
Kawabe, H., et al. J. Biol. Chem. 274(43):30914-30918(1999)
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