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ATRN Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP16370b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP16370b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Citiations : 0
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ATRN Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | O75882 |
| Other Accession | Q99J86, Q9WU60, NP_647537.1, NP_647538.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 158537 Da |
ATRN Antibody (C-term) - Additional info | |
| Gene ID 8455 | |
| Other Names ATRN; KIAA0548; MGCA; Attractin; DPPT-L; Mahogany homolog | |
| Target/Specificity This ATRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1391-1421 amino acids from the C-terminal region of human ATRN. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ATRN Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ATRN Antibody (C-term) - Protein Information | |
| Name ATRN | |
| Synonyms KIAA0548, MGCA | |
| Function Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity) | |
| Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted. | |
| Tissue Location Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes | |
ATRN Antibody (C-term) - Related products
ATRN Antibody (C-term) - Application data
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ATRN Antibody (C-term) (Cat. #AP16370b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the ATRN antibody detected the ATRN protein (arrow).
ATRN Antibody (C-term) - Research Areas
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BACKGROUND
Multiple transcript variants encoding different isoforms exist for this gene. One of the isoforms is a membrane-bound protein with sequence similarity to the mouse mahogany protein, a receptor involved in controlling obesity. The other isoform is a secreted protein involved in the initial immune cell clustering during inflammatory responses that may regulate the chemotactic activity of chemokines.
REFERENCES
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Radhakrishnan, Y., et al. Biol. Reprod. 81(4):647-656(2009) Nan, H., et al. Int. J. Cancer 125(4):909-917(2009) Fernandez, L.P., et al. Exp. Dermatol. 18(7):634-642(2009) Friedrich, D., et al. Biol. Chem. 388(2):155-162(2007)
