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UBP37 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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United States
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Ordering Information
Catalog # SizeAvailability Available Date  
AP16380a 400 µl
(40 western blots)
Backorder 4 months
AP16380a-ev 80 µl
(8 western blots)
Backorder 4 months
  • Specification
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  • Background

UBP37 Antibody (N-term) - Product Information

Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary AccessionQ86T82
Other AccessionF1SRY5, Q8C0R0, F1N5V1, NP_065986.2
ReactivityHuman
PredictedBovine, Mouse, Pig
Immunity Source (Host) Rabbit
Isotype Rabbit Ig
Calculated MW 110170 Da
Antigen Region 67-94

UBP37 Antibody (N-term) - Additional Information

Gene ID 57695
Other Names
USP37; KIAA1594; Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinating enzyme 37; Ubiquitin thioesterase 37; Ubiquitin-specific-processing protease 37
Target/Specificity
This UBP37 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-94 amino acids from the N-terminal region of human UBP37.
Dilution
WB~~1:1000
Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
UBP37 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.

UBP37 Antibody (N-term) - Protein Information

Name USP37
Synonyms KIAA1594
Function
Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'- linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2). {ECO:0000269|PubMed:21596315}.
Tissue Location
Expressed in brain and prostate. {ECO:0000269|PubMed:14715245}

UBP37 Antibody (N-term) - Related Products

BP16380a: UBP37 Antibody (N-term) Blocking Peptide

UBP37 Antibody (N-term) - Research Areas

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BACKGROUND

Belongs to the peptidase C19 family. Contains 3 UIM (ubiquitin-interacting motif) repeats.

REFERENCES

Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)
Quesada, V., et al. Biochem. Biophys. Res. Commun. 314(1):54-62(2004)