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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   UBP37 Antibody (N-term)   

UBP37 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - UBP37 Antibody (N-term) AP16380a
    UBP37 Antibody (N-term) (Cat. #AP16380a) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the UBP37 antibody detected the UBP37 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q86T82
Other Accession F1SRY5, Q8C0R0, F1N5V1, NP_065986.2
Reactivity Human
Predicted Bovine, Mouse, Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 110170 Da
Antigen Region 67-94 aa
Additional Information
Gene ID 57695
Other Names Ubiquitin carboxyl-terminal hydrolase 37, Deubiquitinating enzyme 37, Ubiquitin thioesterase 37, Ubiquitin-specific-processing protease 37, USP37, KIAA1594
Target/Specificity This UBP37 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-94 amino acids from the N-terminal region of human UBP37.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Protein Information
Name USP37
Synonyms KIAA1594
Function Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'- linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2).
Tissue Location Expressed in brain and prostate.
Research Areas
Citations (0)

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Background

Belongs to the peptidase C19 family. Contains 3 UIM (ubiquitin-interacting motif) repeats.

References

Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)
Quesada, V., et al. Biochem. Biophys. Res. Commun. 314(1):54-62(2004)

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Cat# AP16380a
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Quantity:
(40 western blots)
Availability: In Stock
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